产品信息
抗原名称
GPR120
商品描述
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response.
分子量
305.39
纯度
>98%
可溶性
DMSO : ≥ 100 mg/mL (327.45 mM)
外观
white to beige powder
In vitro(体外研究)
GSK137647A (GSK 137647) (50 µM) reduces the production of NO in macrophages without affecting cell viability.
GSK137647A (GSK 137647) (30 µM; 12 hours) alleviates response to inflammatory stimuli in Caco-2 cells and induces secretion of IL-6.
GSK137647A (GSK 137647) (10 µM) reduces the ion flow and affects the colonic epithelial ion transport in healthy.
GSK137647A (GSK 137647) (50 µM) increases glucose stimulated insulin secretion.
GSK137647A (GSK 137647) (30 µM; 12 hours) alleviates response to inflammatory stimuli in Caco-2 cells and induces secretion of IL-6.
GSK137647A (GSK 137647) (10 µM) reduces the ion flow and affects the colonic epithelial ion transport in healthy.
GSK137647A (GSK 137647) (50 µM) increases glucose stimulated insulin secretion.
In vivo(体内研究)
GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) alleviates colitis in TNBS- and DSS-treated mice.
背景
分子式
C16H19NO3S
CAS号
349085-82-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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