产品信息
抗原名称
Rac1
商品描述
EHop-016 is a novel inhibitor of Rac GTPase with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3.
分子量
430.55
纯度
>98%
可溶性
DMSO Solubility: 86 mg/mL (199.74 mM)
外观
Powder
In vitro(体外研究)
Rac inhibition by EHop-016 increases the activity of the closely related Rho GTPase RhoA by a compensatory mechanism. In MDA-MB-435 cells, EHop-016 (2-5 μM) inhibits association of active Vav2 with Rac1(G15A) mutant fusion protein, and reduces Rac-regulated cell functions including lamellipodia formation and cell migration. In addition, EHop-016 inhibits cell viability of MDA-MB-435 cells with IC50 of 10 μM. EHop-016 also inhibits KITD814V-induced growth in SM and AML patients-derived cells.
In vivo(体内研究)
Treatment of KITD814V-bearing cells with EHop-016 significantly enhances the survival of leukemic mice.
背景
别名
Ehop 016,EHop016
分子式
C25H30N6O
CAS号
1380432-32-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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