产品信息
抗原名称
ROR
商品描述
SR1001 is a high-affinity synthetic ligand of RORα and RORγ; suppresses TH17 cell differentiation and inhibits autoimmunity.
分子量
477.4
纯度
>98%
可溶性
DMSO : 50 mg/mL (104.73 mM)
外观
white to beige powder
In vitro(体外研究)
SR1001 inhibits the development of murine TH17 cells by inhibition of IL-17A gene expression and protein production. SR1001 reduces the interaction of a coactivator TRAP220 NR box 2 peptide with RORγ in a dose dependent manner (IC50 value≈117 nM). Additionally, SR1001 inhibits the expression of cytokines when added to differentiated murine or human TH17 cells.
In vivo(体内研究)
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice. Administration of SR1001 to C57BL/6 mice suppresses the expression of hepatic ROR target genes, Cyp7b1, Rev-erbα, and Serpine 1. SR1001 a RORα inverse agonist eliminats the circadian pattern of expression of citrate synthase mRNA in mice.
背景
别名
SR-1001；SR 1001
分子式
C15H13F6N3O4S2
CAS号
1335106-03-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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