产品信息
抗原名称
MetAP2
商品描述
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (<b>MetAP2</b>), used as an antibiotic to treat microsporidiosis.
分子量
458.54
纯度
98%
可溶性
Ethanol : 1.2 mg/mL (2.5 mM)
外观
白色粉末
In vitro(体外研究)
Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases.
In vivo(体内研究)
In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis.
背景
别名
烟曲霉素
分子式
C26H34O7
CAS号
23110-15-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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