产品信息
抗原名称
dopamine D1 receptor,D5 receptor
商品描述
SKF38393 HCl is a selective <b>dopamine D1/D5 receptor</b> agonist.
分子量
291.77
纯度
98%
可溶性
DMSO : 54 mg/mL (185.1 mM)
Ethanol ：6 mg/mL (20.56 mM), warmed
Ethanol ：6 mg/mL (20.56 mM), warmed
外观
white powder
In vitro(体外研究)
SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.
In vivo(体内研究)
SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
背景
别名
SKF 38393 hydrochloride；(±)-SKF-38393 hydrochloride；SKF-38393A
分子式
C16H17NO2 . HCl
CAS号
62717-42-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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