产品信息
抗原名称
tau protein aggregation
商品描述
TRx 0237 (LMTX) mesylate is a second-generation <b>tau protein aggregation</b> inhibitor for the treatment of Alzheimer‘s disease (AD) and frontotemporal dementia.
分子量
477.62
纯度
＞98%
可溶性
DMSO ：95mg/mL(198.9mM)
Water ：95mg/mL(198.9mM)
Water ：95mg/mL(198.9mM)
In vitro(体外研究)
TRx 0237 (LMTX) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM.
In vivo(体内研究)
TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66.
背景
别名
Leucomethylene blue Mesylate；Methylene blue leuco base mesylate salt
分子式
C16H19N3S.2CH4O3S
CAS号
1236208-20-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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