产品信息
抗原名称
pregnane X receptor,HMG-CoA reductase
商品描述
SR-12813 is a <b>pregnane X receptor (PXR)</b> agonist.
分子量
504.53
纯度
98%
可溶性
DMSO : 50.5 mg/mL (100 mM)
Ethanol : 50.5 mg/mL (100 mM)
Ethanol : 50.5 mg/mL (100 mM)
外观
Beige solid
In vitro(体外研究)
SR12813 is a very potent and efficacious activator of both the human and rabbit PXR, with EC50 values of approximately 200 nM and 700 nM, respectively. By contrast, SR12813 is only a very weak activator of the rat and mouse PXR. SR-12813 inhibits incorporation of tritiated water into cholesterol with an IC50 of 1.2 μM but has no effect on fatty acid synthesis. SR-12813 reduces cellular 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity with an IC50 of 0.85 μM. The inhibition of HMG-CoA reductase activity is rapid with a T1/2 of 10 min.
In vivo(体内研究)
The bisphosphonate ester SR12813 lowers cholesterol levels in a range of species including rats, dogs and primates.
背景
别名
SR12813；SR 12813
分子式
C24H42O7P2
CAS号
126411-39-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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