产品信息
抗原名称
Lyn kinase
商品描述
MLR-1023 is a chemical compound which inhibits <b>acid secretion</b> in animal models and also acts as a bronchodilator in histamine-challenged animals.
分子量
202.21
纯度
＞98%
可溶性
体外:
DMSO 40mg/mL(197.81mM)
Ethanol 23mg/mL(113.74mM)
Water <1mg/mL
DMSO 40mg/mL(197.81mM)
Ethanol 23mg/mL(113.74mM)
Water <1mg/mL
In vitro(体外研究)
In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism.
In vivo(体内研究)
MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onsetand durable blood glucose-lowering activity in diabetic animals.
背景
分子式
C11H10N2O2
CAS号
41964-07-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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