产品信息
抗原名称
Na(addition)_K(addition) ATPase
商品描述
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
分子量
360.49
纯度
>98%
可溶性
10 mM in DMSO
In vitro(体外研究)
Istaroxime acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase. Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
In vivo(体内研究)
Istaroxime (PST2744) induces a progressive increase in +dP/dtmax throughout the infusion that reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg.
背景
别名
PST2744；PST 2744； Istaroxime； Debio 0614；Debio0614
分子式
C21H32N2O3
CAS号
203737-93-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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