产品信息
抗原名称
Aldose Reductase
商品描述
Tolrestat is an aldose reductase inhibitor[1] which was approved for the control of certain diabetic complications.
分子量
357.35
纯度
>98%
可溶性
DMSO: soluble20 mg/mL
In vivo(体内研究)
Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.
背景
别名
AY-27773,AY 27773, AY27773
分子式
C16H14F3NO3S
CAS号
82964-04-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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