BD Pharmingen- Purified Mouse Anti-Human vWF_BD Pharmingen
产品信息
抗原名称
vWF
宿主
Mouse IgG1, κ
简单描述
Reacts with von Willebrand Factor (vWF), a multimeric plasma glycoprotein synthesized by endothelial cells and megakaryocytes. In plasma, vWF circulates as multimers which range from dimers of about 500 kDa to multimers of 20000 kDa. It functions as a carrier for Factor VIII and is a mediator of initial platelet adhesion to subendothelium and platelet-platelet interaction. Platelets bind to vWF through the platelet GPIb/IX (CD42b/CD42a) and GPIIb/IIIa (CD41/CD61) complexes This antibody is effective in detecting vWF by ELISA, with no evidence of cross reactivity with fibronectin or fibrinogen.
商品描述
2F2-A9
Reacts with von Willebrand Factor (vWF), a multimeric plasma glycoprotein synthesized by endothelial cells and megakaryocytes. In plasma, vWF circulates as multimers which range from dimers of about 500 kDa to multimers of 20000 kDa. It functions as a carrier for Factor VIII and is a mediator of initial platelet adhesion to subendothelium and platelet-platelet interaction. Platelets bind to vWF through the platelet GPIb/IX (CD42b/CD42a) and GPIIb/IIIa (CD41/CD61) complexes This antibody is effective in detecting vWF by ELISA, with no evidence of cross reactivity with fibronectin or fibrinogen.
同种型
Mouse IgG1, κ
克隆号
克隆 2F2-A9 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Immunohistochemistry-frozen (Routinely Tested)
反应种属
Human (QC Testing)
目标/特异性
vWF
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(2)
1. Ginsburg D, Bockenstedt PL, Allen EA, et al. Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. Thromb Haemost. 1991; 67(1):166-171. (Clone-specific: Immunohistochemistry).
2. Sadler JE. von Willebrand factor. J Biol Chem. 1991; 266(34):22777-22780. (Clone-specific: Immunohistochemistry).
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