BD Pharmingen- Purified Hamster Anti-Mouse CD29_BD Pharmingen
产品信息
抗原名称
CD29 (Integrin β1)
宿主
Armenian Hamster IgG2, λ1
免疫原
Purified mouse VLA-4
简单描述
The HM β1-1 monoclonal antibody specifically binds to the 130-kDa integrin β1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin-α chains. With α1 through α6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with αv (CD51), it forms αvβ1 integrin. It also associates with the integrin α7 α8, and α9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, epithelia, and oocytes. This hamster mAb to a mouse leukocyte antigen has been observed to crossreact with similar populations of rat leukocytes. Source of the immunogen was purified mouse VLA-4 (α4β1, CD49d/CD29).
商品描述
HM β1-1
The HM β1-1 monoclonal antibody specifically binds to the 130-kDa integrin β1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin-α chains. With α1 through α6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with αv (CD51), it forms αvβ1 integrin. It also associates with the integrin α7 α8, and α9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, epithelia, and oocytes. This hamster mAb to a mouse leukocyte antigen has been observed to crossreact with similar populations of rat leukocytes. Source of the immunogen was purified mouse VLA-4 (α4β1, CD49d/CD29).
同种型
Armenian Hamster IgG2, λ1
克隆号
克隆 HM β1-1 (RUO)
浓度
15.625 µg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested), Immunohistochemistry-frozen (Tested During Development), Immunohistochemistry-formalin (antigen retrieval required) (Not Recommended)
反应种属
Mouse (QC Testing), Rat (Tested in Development)
目标/特异性
CD29 (Integrin β1)
背景
别名
Itgb1; Integrin beta-1; Fnrb; gpIIa; VLA-4 subunit beta
制备和贮存
存储溶液
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
文献
文献
研发参考(3)
1. Jackson Laboratory. Mouse Genome Database. Available: http://www.informatics.jax.org/ 1998, Sept. 17.
2. Noto K, Kato K, Okumura K, Yagita H. Identification and functional characterization of mouse CD29 with a mAb. Int Immunol. 1995; 7(5):835-842. (Immunogen).
3. Springer TA. Adhesion receptors of the immune system. Nature. 1990; 346(6283):425-434. (Biology).
参考图片
Immunohistochemical staining of CD29 positive cells. Frozen sections of normal mouse spleen were stained with Purified Hamster Anti-Mouse CD29 (Cat. No. 550530) antibody. Endothelial cells of the central arteriole and splenic sinuses can be identified by the brown labeling of their cell membranes. Amplification 20X.
Immunohistochemical staining of CD29 positive cells. Frozen sections of normal mouse spleen were stained with Purified Hamster Anti-Mouse CD29 (Cat. No. 550530) antibody. Endothelial cells of the central arteriole and splenic sinuses can be identified by the brown labeling of their cell membranes. Amplification 20X.
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