BD Pharmingen- Purified Rat Anti-Mouse CD105_BD Pharmingen
产品信息
抗原名称
CD105
宿主
Rat IgG2a, κ
免疫原
Mouse skin (inflamed)
简单描述
The MJ7/18 monoclonal antibody specifically binds to mouse CD105 (also known as endoglin) which is a homodimer of 90-kDa subunits and is predominantly expressed on vascular endothelial cells. High levels of mouse endoglin mRNA have been reported to be detectable in the ovary, uterus, NCTC-2071 fibroblasts, and to a lesser extent, in heart, muscle and stromal cells in connective tissue of various organs. Endoglin has been reported to play an essential role in embryonic angiogenesis. Both mouse and human endoglin display strong amino-acid sequence homology to the transmembrane and cytoplasmic regions of the type III TGF-ß receptor.
商品描述
MJ7/18
The MJ7/18 monoclonal antibody specifically binds to mouse CD105 (also known as endoglin) which is a homodimer of 90-kDa subunits and is predominantly expressed on vascular endothelial cells. High levels of mouse endoglin mRNA have been reported to be detectable in the ovary, uterus, NCTC-2071 fibroblasts, and to a lesser extent, in heart, muscle and stromal cells in connective tissue of various organs. Endoglin has been reported to play an essential role in embryonic angiogenesis. Both mouse and human endoglin display strong amino-acid sequence homology to the transmembrane and cytoplasmic regions of the type III TGF-ß receptor.
同种型
Rat IgG2a, κ
克隆号
克隆 MJ7/18 (RUO)
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested), Immunohistochemistry-frozen (Tested During Development), Immunohistochemistry-formalin (antigen retrieval required) (Not Recommended)
反应种属
Mouse (QC Testing)
目标/特异性
CD105 (Endoglin)
背景
别名
Endoglin; Edg; EGLN; Eng; MJ7/18 antigen; S-endoglin
制备和贮存
存储溶液
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
参考图片
Immunohistochemical staining of CD105 (Endoglin). Frozen sections of normal mouse spleen were stained with the rat anti-mouse CD105 antibody (clone MJ7/18). Cells expressing CD105 can be identified by the brown labeling of their cell membranes (Magnification 20X).
Immunohistochemical staining of CD105 on mouse splenocytes. Frozen sections of normal mouse spleen were stained with Purified Rat Anti-Mouse CD105 (Cat. No. 550546). Visualization of CD105 was carried out with Biotin Goat Anti-Rat Ig (Cat. No. 559286) and Streptavidin HRP (Cat. No. 550946). (Magnification 20x)
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