Purified Rat Anti-Human IL-12R-2-2B6-12beta2_BD Pharmingen
产品信息
荧光素标记
Unconjugated
抗原名称
CD212 (IL-12 Receptor β1)
宿主
Rat IgG2a, κ
免疫原
Human IL-12Rβ2 Recombinant Protein
简单描述
The 2B6 monoclonal antibody specifically recognizes the Interleukin 12 Receptor beta 2 subunit (IL-12Rβ2). IL-12Rβ2 serves as the signaling subunit that combines with CD212 (Interleukin 12 Receptor beta 1 subunit/ IL-12Rβ1) to form the functional receptor for IL-12. The IL-12Rβ2 is expressed on T cells and NK cells. IL-12R is a glycoprotein member of the hemopoietin receptor superfamily and is related to gp130, the granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). IL-12 is an immunomodulatory cytokine produced mainly by antigen presenting cells (APC) and plays a role in promoting Th1-type responses and cell mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine activated (LAK) cells and cytolytic T cells (CTL).
商品描述
The 2B6 monoclonal antibody specifically recognizes the Interleukin 12 Receptor beta 2 subunit (IL-12Rβ2). IL-12Rβ2 serves as the signaling subunit that combines with CD212 (Interleukin 12 Receptor beta 1 subunit/ IL-12Rβ1) to form the functional receptor for IL-12. The IL-12Rβ2 is expressed on T cells and NK cells. IL-12R is a glycoprotein member of the hemopoietin receptor superfamily and is related to gp130, the granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). IL-12 is an immunomodulatory cytokine produced mainly by antigen presenting cells (APC) and plays a role in promoting Th1-type responses and cell mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine activated (LAK) cells and cytolytic T cells (CTL).
同种型
Rat IgG2a, κ
克隆号
2B6/12beta2
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested) Fluorescence microscopy (Reported)
反应种属
Human (QC Testing)
背景
别名
IL12RB2; Interleukin-12 receptor beta-2 chain
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(4)
1. Chizzonite R, Truitt T, Podlaski FJ, et al. IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J Immunol. 1991; 147(5):1548-1556. (Biology).
2. Chua AO, Chizzonite R, Desai BB, et al. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol. 1994; 153(1):128-136. (Biology).
3. Presky DH, Minetti LJ, Gillessen S, et al. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J Immunol. 1998; 160(5):2174-2179. (Biology).
4. Wu CY, Warrier RR, Carvajal DM, et al. Biological function and distribution of human interleukin-12 receptor beta chain. Eur J Immunol. 1996; 26(2):345-350. (Biology).
参考图片
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