BD Pharmingen- PE Mouse Anti-Human CD112_BD Pharmingen
产品信息
荧光素标记
PE
抗原名称
CD112
宿主
Mouse IgG1, κ
简单描述
The R2.525 monoclonal antibody specifically binds to CD112. CD112 is a type I transmembrane glycoprotein that is encoded by
NECTIN2
(Nectin cell adhesion molecule 2) which belongs to the Ig gene superfamily. CD112 is also known as polio virus related receptor 2 (PRR2), poliovirus receptor-like 2 (PVRL2) or herpesvirus entry protein B (HveB). CD112 is a cell surface molecule homologous to the poliovirus receptor (PVR/CD155). The
NECTIN2
gene codes for two mRNA isoforms, a short form of 3.0 kb (hPRR2α) and a long form of 4.4 kb (hPRR2δ). Both are widely expressed in human tissues, including hematopoietic cells. CD112 is also expressed on endothelial cells, at the intercellular junctions of adjacent cells. PRR2 may play a role in the regulation of hematopoietic/endothelial cell interactions.
商品描述
R2.525
The R2.525 monoclonal antibody specifically binds to CD112. CD112 is a type I transmembrane glycoprotein that is encoded by
NECTIN2
(Nectin cell adhesion molecule 2) which belongs to the Ig gene superfamily. CD112 is also known as polio virus related receptor 2 (PRR2), poliovirus receptor-like 2 (PVRL2) or herpesvirus entry protein B (HveB). CD112 is a cell surface molecule homologous to the poliovirus receptor (PVR/CD155). The
NECTIN2
gene codes for two mRNA isoforms, a short form of 3.0 kb (hPRR2α) and a long form of 4.4 kb (hPRR2δ). Both are widely expressed in human tissues, including hematopoietic cells. CD112 is also expressed on endothelial cells, at the intercellular junctions of adjacent cells. PRR2 may play a role in the regulation of hematopoietic/endothelial cell interactions.
同种型
Mouse IgG1, κ
克隆号
克隆 R2.525 (RUO)
产品详情
PE
R-Phycoerythrin (PE), is part of the BD family of Phycobiliprotein dyes. This fluorochrome is a multimeric fluorescent phycobiliprotein with excitation maximum (Ex Max) of 496 nm and 566 nm and an emission maximum (Em Max) at 576 nm. PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 575/26-nm bandpass filter). As PE is excited by multiple lasers, this can result in cross-laser excitation and fluorescence spillover on instruments with various combinations of Blue, Green, and Yellow-Green lasers. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
PE
Yellow-Green 488 nm, 532 nm, 561 nm
496 nm, 566 nm
576 nm
应用
实验应用
Flow cytometry (Routinely Tested)
推荐用量
20 µl
反应种属
Human (QC Testing)
目标/特异性
CD112 (Nectin-2)
背景
别名
HVEB; PRR2; PVRL2; PVRR2; NECTIN2; nectin-2; nectin 2
制备和贮存
存储溶液
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
文献
文献
研发参考(2)
1. Eberle F, Dubreuil P, Mattei MG, Devilard E, Lopez M. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene. 1995; 159(2):267-272. (Biology).
2. Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood. 1998; 92(12):4602-4611. (Biology).
参考图片
Profile of HL-60 cell line analyzed by flow cytometry
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