BD Pharmingen- Purified Rat Anti-Mouse Follicular Dendritic Cell_BD Pharmingen
产品信息
抗原名称
FDC
宿主
Rat IgG2c, κ
简单描述
Follicular Dendritic Cells (FDC) form a structural network within the lymphoid follicles and are involved in antigen presentation to B cells for generating an immune response and for the maintenance of immunological memory. FDCs are believed to provide signals to B cells to induce their proliferation. In LCMV mediated immunosuppression there is evidence of T-cell dependent destruction of macrophages and follicular dendritic cells. The FDC-M1 antibody recognizes follicular dendritic cells and their dendritic processes.
商品描述
FDC-M1
Follicular Dendritic Cells (FDC) form a structural network within the lymphoid follicles and are involved in antigen presentation to B cells for generating an immune response and for the maintenance of immunological memory. FDCs are believed to provide signals to B cells to induce their proliferation. In LCMV mediated immunosuppression there is evidence of T-cell dependent destruction of macrophages and follicular dendritic cells. The FDC-M1 antibody recognizes follicular dendritic cells and their dendritic processes.
同种型
Rat IgG2c, κ
克隆号
克隆 FDC-M1 (RUO)
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Immunohistochemistry-frozen (Routinely Tested), Immunohistochemistry-formalin (antigen retrieval required) (Not Recommended)
反应种属
Mouse (QC Testing)
目标/特异性
FDC
制备和贮存
存储溶液
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
文献
文献
研发参考(3)
1. Gray D, Kosco M, Stockinger B. Novel pathways of antigen presentation for the maintenance of memory. Int Immunol. 1991; 3(2):141-148. (Biology).
2. Kosco, Pflugfelder, and Gray. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. . J Immunol. 1992; 148:2331-2339. (Biology).
3. Odermatt B, Eppler M, Leist TP, Hengartner H, Zinkernagel RM. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A. 1991; 88(18):8252-8256. (Biology).
参考图片
Immunohistochemistry of follicular dendritic cells. Frozen sections of mouse spleen was reacted with the FDC-M1 antibody. Follicular dendritic cells can be identified by the intense brown labeling of their cell membranes. Magnification 20X.
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