BD Pharmingen- Purified Mouse Anti-Rat CD9_BD Pharmingen
产品信息
抗原名称
CD9
宿主
Mouse IgG3, κ
免疫原
Not Reported
简单描述
The RPM.7 monoclonal antibody specifically recognizes CD9, a 26-kDa member of the transmembrane 4 superfamily. Rat CD9 mRNA is detected in many adult tissues, including neural and hematopoietic tissue. Using RPM.7 mAb in flow cytometric analysis of rat hematopoietic tissues, CD9 is found on platelets, peripheral B- and T-lymphocyte subsets, and leukocyte subpopulations in the bone marrow. In humans, CD9 has been found to be associated with integrins and other cell-surface receptors, and it is suggested to play a role in signal transduction and possibly in regulating cellular adhesive properties. In mice, CD9 has been demonstrated to participate in T-cell costimulation and induction of apoptosis.
商品描述
RPM.7
The RPM.7 monoclonal antibody specifically recognizes CD9, a 26-kDa member of the transmembrane 4 superfamily. Rat CD9 mRNA is detected in many adult tissues, including neural and hematopoietic tissue. Using RPM.7 mAb in flow cytometric analysis of rat hematopoietic tissues, CD9 is found on platelets, peripheral B- and T-lymphocyte subsets, and leukocyte subpopulations in the bone marrow. In humans, CD9 has been found to be associated with integrins and other cell-surface receptors, and it is suggested to play a role in signal transduction and possibly in regulating cellular adhesive properties. In mice, CD9 has been demonstrated to participate in T-cell costimulation and induction of apoptosis.
同种型
Mouse IgG3, κ
克隆号
克隆 RPM.7 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested), Immunoprecipitation, Western blot (Reported)
反应种属
Rat (QC Testing)
目标/特异性
CD9
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(6)
1. Claas C, Wahl J, Orlicky DJ, et al. The tetraspanin D6.1A and its molecular partners on rat carcinoma cells. Biochem J. 2005; 389(Pt 1):99-110. (Clone-specific: Immunoprecipitation).
2. Jennings LK, Crossno JT Jr, Fox CF, White MM, Green CA. Platelet p24/CD9, a member of the tetraspanin family of proteins. Ann N Y Acad Sci. 1994; 714:175-184. (Biology).
3. Kaprielian Z, Cho KO, Hadjiargyrou M, Patterson PH. CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system. J Neurosci. 1995; 15(1):562-573. (Biology).
4. Park CS, Yashiro Y, Tai XG, et al. Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells.. J Immunol. 1998; 160(12):5790-6. (Biology).
5. Terada N, Baracskay K, Kinter M, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia. 2002; 40(3):350-359. (Clone-specific: Immunoprecipitation).
6. Wright MD, Tomlinson MG. The ins and outs of the transmembrane 4 superfamily. Immunol Today. 1994; 15(12):588-594. (Biology).
参考图片
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