FUT-175 (Futhan, or Nafamostat Mesilate, chemical name: 6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate) is a synthetic, broad-specificity protease inhibitor and an inhibitor of the classical and alternate pathways of complement activation. The molecular weight of Futhan is 539.58 Da.

(RUO)

FUT-175 (Futhan)

Lyophilized powder

Development References(7) 1. Hecke F, Schmidt U, Kola A, Bautsch W, Klos A, Kohl J. Circulating complement proteins in multiple trauma patients--correlation with injury severity, development of sepsis, and outcome. Crit Care Med. 1997; 25(12):2015-2024. (Biology). 2. Ikari N, Sakai Y, Hitomi Y, Fujii S. New synthetic inhibitor to the alternative complement pathway. Immunology. 1983; 49(4):685-691. (Biology). 3. Inagi R, Miyata T, Maeda K, Sugiyama S, Miyama A, Nakashima I. FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a. Immunol Lett. 1991; 27(1):49-52. (Biology). 4. Issekutz AC, Roland DM, Patrick RA. The effect of FUT-175 (Nafamstat Mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo. Int J Immunopharmacol. 1990; 12(1):1-9. (Biology). 5. Pfeifer PH, Kawahara MS, Hugli TE. Possible mechanism for in vitro complement activation in blood and plasma samples: futhan/EDTA controls in vitro complement activation. Clin Chem. 1999; 45(8):1190-1199. (Biology). 6. Stove S, Welte T, Wagner TO, et al. Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome. Clin Diagn Lab Immunol. 1996; 3(2):175-183. (Biology). 7. Watkins J, Wild G, Smith S. Nafamostat to stabilise plasma samples taken for complement measurements. Lancet. 1989; 1(8643):896-897. (Biology).