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BD Pharmingen- Purified Mouse Anti-Human CD121b_BD Pharmingen

艾美捷科技 • 2025年08月20日 13:21:42 • 抗体 • 阅读 6 • 标签
产品信息
抗原名称
CD121b
宿主
Mouse IgG1, κ
免疫原
Human IL-1 Receptor Type II
简单描述
CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the formation of signaling complexes. Membrane IL-1 type II receptor forms a 60 kDa soluble IL-1 receptor type II upon proteolytic cleavage from various cell types after activation with secondary, IL-1 induced cytokines. The soluble IL-1 type II receptor consists of 398 amino acids and 29 amino acids within a short cytoplasmic domain. The MNC2 monoclonal antibody reacts with recombinant and native soluble human IL-1 receptor type II.
商品描述
MNC2 CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the formation of signaling complexes. Membrane IL-1 type II receptor forms a 60 kDa soluble IL-1 receptor type II upon proteolytic cleavage from various cell types after activation with secondary, IL-1 induced cytokines. The soluble IL-1 type II receptor consists of 398 amino acids and 29 amino acids within a short cytoplasmic domain. The MNC2 monoclonal antibody reacts with recombinant and native soluble human IL-1 receptor type II.
同种型
Mouse IgG1, κ
克隆号
克隆 MNC2 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
ELISA (Routinely Tested), Flow cytometry (Tested During Development)
反应种属
Human (QC Testing)
目标/特异性
CD121b (IL-1 Receptor 2)
背景
别名
IL-1 Receptor Type II; IL-1 RII; IL-1RB; IL-1R-2
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(3) 1. Bessis N, Guéry L, Mantovani A, et al. The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis. Eur J Immunol. 2000 March; 30(3):867-875. (Biology). 2. Neumann D, Kollewe C, Martin MU, Boraschi D. The membrane form of the type II IL-1 receptor accounts for inhibitory function. J Immunol. 2000 Septembr; 165(6):3350-3357. (Biology). 3. Orlando S, Sironi M, Bianchi G, et al. Role of metalloproteases in the release of the IL-1 type II decoy receptor. J Biol Chem. 1997 December; 272(50):31764-31769. (Biology).

参考图片

Flow cytometric analysis for CD121b. Jurkat cells (Human T-cell leukemia; ATCC TIB-152) [Left Panel] or SR cells (Human lymphoblast; ATCC CRL-2262) [Right Panel] were stained either with a Mouse IgG1, κ isotype control (MN 555746) [dotted line] or with the Purified Mouse Anti-Human CD121b antibody (MN 552401) [solid line] in conjunction with a PE Goat Anti-Mouse Ig secondary antibody (MN 550589). Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.

Flow cytometric analysis for CD121b expression on human cell lines. Jurkat cells (Human T-cell leukemia; ATCC TIB-152; Left Panel) or SR cells (Human lymphoblast; ATCC CRL-2262, Right Panel) were stained either with a Mouse IgG1, κ isotype control (Cat. No. 555746; dotted line histogram) or with the Purified Mouse Anti-Human CD121b antibody (Cat. No. 552401; solid line histogram) in conjunction with a PE Goat Anti-Mouse Ig secondary antibody (Cat. No. 550589).  Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.

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