BD Pharmingen- FITC Mouse Anti-Human CD41a_BD Pharmingen-艾美捷科技

BD Pharmingen- FITC Mouse Anti-Human CD41a_BD Pharmingen

艾美捷科技 • 2025年08月25日 15:26:32 • 抗体 • 阅读 84 • 标签

产品信息

荧光素标记

FITC

抗原名称

CD41a

宿主

Mouse BALB/c IgG1, κ

免疫原

Purified platelet membrane glycoproteins

简单描述

The HIP8 monoclonal antibody specifically binds to the α-chain of CD41. CD41 is also known as Integrin αIIb or Platelet GPIIb. The calcium-dependent complex of CD41 and CD61 (β3 integrin or GPIIIa) is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. CD41 (clone HIP8) completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes. Clone HIP8 also cross-reacts with a major subset of peripheral blood platelets of baboon, and both rhesus and cynomolgus macaque monkeys. The staining pattern of platelets is similar to that observed with peripheral blood platelets from normal human donors.

商品描述

HIP8 The HIP8 monoclonal antibody specifically binds to the α-chain of CD41. CD41 is also known as Integrin αIIb or Platelet GPIIb. The calcium-dependent complex of CD41 and CD61 (β3 integrin or GPIIIa) is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. CD41 (clone HIP8) completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes. Clone HIP8 also cross-reacts with a major subset of peripheral blood platelets of baboon, and both rhesus and cynomolgus macaque monkeys. The staining pattern of platelets is similar to that observed with peripheral blood platelets from normal human donors.

同种型

Mouse BALB/c IgG1, κ

克隆号

克隆 HIP8 (RUO)

产品详情

FITC

Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.

格式:FITC

激发源:Blue 488 nm

最多激发源:494 nm

最多发射源:518 nm

应用

实验应用

Flow cytometry (Routinely Tested)

推荐用量

20 µl

反应种属

Human (QC Testing), Rhesus, Cynomolgus, Baboon (Tested in Development)

目标/特异性

CD41a

背景

别名

ITGA2B; Integrin alpha-2b (αIIb); Platelet glycoprotein IIb (GPIIb)

制备和贮存

存储溶液

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

保存方式

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

文献

研发参考(2) 1. Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1-1182. 2. Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995.

数据库链接

Entrez-Gene ID

3674

BD Pharmingen- FITC Mouse Anti-Human CD41a_BD Pharmingen

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