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BD Pharmingen- FITC Rat Anti-Mouse V-4 T-Cell Receptor_BD Pharmingen

艾美捷科技 • 2025年08月21日 10:10:12 • 抗体 • 阅读 38 • 标签
产品信息
荧光素标记
FITC
抗原名称
TCR Vβ4
宿主
Rat SD, also known as Sprague-Dawley (outbred) IgG2b, κ
免疫原
KT4 B10.D2 mouse T-cell clone I3
简单描述
The KT4 antibody specifically recognizes the Vβ4 T-cell Receptor (TCR) of mice having the a ( e.g ., C57BR, C57L, SJL, SWR), b ( e.g ., A, AKR, BALB/c, CBA, C3H/He, C57BL, C58, DBA/1, DBA/2), and c ( e.g ., RIII) haplotypes of the Tcrb gene complex. Vβ4 TCR-bearing cells are among the CD4+ autoreactive T cells which induce autoimmune thyroiditis after elimination of regulatory (CD5-bright) T-cell subsets. Plate-bound KT4 antibody activates Vβ4 TCR-bearing T cells.
商品描述
KT4 The KT4 antibody specifically recognizes the Vβ4 T-cell Receptor (TCR) of mice having the a ( e.g ., C57BR, C57L, SJL, SWR), b ( e.g ., A, AKR, BALB/c, CBA, C3H/He, C57BL, C58, DBA/1, DBA/2), and c ( e.g ., RIII) haplotypes of the Tcrb gene complex. Vβ4 TCR-bearing cells are among the CD4+ autoreactive T cells which induce autoimmune thyroiditis after elimination of regulatory (CD5-bright) T-cell subsets. Plate-bound KT4 antibody activates Vβ4 TCR-bearing T cells.
同种型
Rat SD, also known as Sprague-Dawley (outbred) IgG2b, κ
克隆号
克隆 KT4 (RUO)
浓度
0.5 mg/ml
产品详情
FITC
Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
FITC
Blue 488 nm
494 nm
518 nm
应用
实验应用
Flow cytometry (Routinely Tested)
反应种属
Mouse (QC Testing)
目标/特异性
TCR Vβ4
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(3) 1. Katz JD, Benoist C, Mathis D. T helper cell subsets in insulin-dependent diabetes. Science. 1995; 268(5214):1185-1188. (Biology). 2. Sugihara S, Fujiwara H, Shearer GM. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions. J Immunol. 1993; 150(2):683-694. (Biology). 3. Tomonari K, Lovering E, Spencer S. Correlation between the V beta 4+ CD8+ T-cell population and the H-2d haplotype. Immunogenetics. 1990; 31(5-6):333-339. (Immunogen).

参考图片

Two-color analysis of the expression of Vβ4 TCR on peripheral T lymphocytes. C57BL/6 lymph node cells were incubated simultaneously with FITC-conjugated KT4, PE-conjugated RM4-5 (anti-CD4, Cat. no. 553048/553049), and PE-conjugated 53-6.7 (anti-CD8a, Cat. no. 553032/553033) monoclonal antibodies. Flow cytometry was performed on a FACScan™ (BDIS, San Jose, CA).

Two-color analysis of the expression of Vβ4 TCR on peripheral T lymphocytes. C57BL/6 lymph node cells were incubated simultaneously with FITC-conjugated KT4, PE-conjugated RM4-5 (anti-CD4, Cat. no. 553048/553049), and PE-conjugated 53-6.7 (anti-CD8a, Cat. no. 553032/553033) monoclonal antibodies. Flow cytometry was performed on a FACScan™ (BDIS, San Jose, CA).

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