Lymphotoxin (LT-α), also known as, Tumor Necrosis Factor-β (TNF-β) is a potent multifunctional cytokine which is primarily produced by activated lymphocytes.  LT-α has cytotoxic activity against a wide range of tumor cells and certain other target cells.  Other LT-α activities include the activation of neutrophils, osteoclasts, and endothelial cells and the upregulation of the membrane expression of MHC antigens and adhesion molecules by various cell types.  Human LT-α is a 18 kDa protein containing 171 amino acid residues.   Recombinant human LT-α (Cat. No. 554619) is supplied as a frozen liquid comprised of 0.22 µm sterile-filtered aqueous buffered solution, containing  bovine serum albumin, with no preservatives.  Recombinant human LT-α  is  ≥ 95% pure as determined by SDS-PAGE analysis, and an absorbance assay based on the Beers-Lambert Law.  The endotoxin level is ≤0.1 ng per µg of LT-α, as measured in a chromogenic LAL assay.

(RUO)

200 µg/ml

ELISA Standard (Routinely Tested), Bioassay (Tested During Development)

Human (QC Testing)

LT-α

Frozen aqueous buffered solution containing BSA.

Development References(1) 1. Paul NL, Ruddle NH. Lymphotoxin. Annu Rev Immunol. 1988; 6:407-438. (Biology).